1P-LSD
Common Names: Propionyl-d-lysergic, P-LSD, It, LSD, P-LSD
Psychoactive Effects
Positive Effects
- Euphoria
Neutral Effects
- Time distortion
- Visual hallucinations
- Synesthesia
- Altered thought patterns
- Enhanced sensory perception
- Ego dissolution
Negative Effects
- Anxiety
- Paranoia
- Panic
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 25-50 μg | 50-100 μg | 100-200 μg | 200-400 μg | 400+ μg |
Note: 1P-LSD is approximately equipotent to LSD-25. The propionyl group is metabolized to form LSD-25 as an active metabolite.
Duration
| Phase | Duration |
|---|---|
| Onset | 30-90 minutes |
| Peak | 2-4 hours |
| Total | 8-12 hours |
| After effects | 6-12 hours |
Pharmacology
Mechanism of Action: 1P-LSD acts as a partial agonist at serotonin 5-HT2A receptors. The propionyl group is metabolized to form LSD-25 as an active metabolite.
Metabolism: Metabolized in the liver primarily by CYP3A4 and CYP2D6 enzymes. The propionyl group is hydrolyzed to form LSD-25.
Half-life: Approximately 3-5 hours, with active metabolites extending the duration of effects.
Bioavailability: ~70% when taken orally, with peak plasma concentrations reached within 1-2 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Brandt, S. D., et al. (2017). Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD). Drug Testing and Analysis, 8(9), 891-902.
- • Nichols, D. E. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264-355.
- • Halberstadt, A. L., & Geyer, M. A. (2018). Effect of hallucinogens on unconditioned behavior. Current Topics in Behavioral Neurosciences, 36, 159-199.
- • Information compiled from PsychonautWiki