2C-B
Common Names: Bromo-2, Nexus, Bromo, Mescaline, BDMPEA
Psychoactive Effects
Positive Effects
- Euphoria
- Pleasure
Neutral Effects
- Visual hallucinations
- Time distortion
- Enhanced colors
- Geometric patterns
- Altered body perception
- Enhanced tactile sensations
Negative Effects
- Anxiety
- Paranoia
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 2-5 mg | 5-15 mg | 15-25 mg | 25-40 mg | 40+ mg |
| Insufflated | 1-3 mg | 3-8 mg | 8-15 mg | 15-25 mg | 25+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | 30-60 minutes |
| Peak | 2-4 hours |
| Total | 4-8 hours |
| After effects | 2-4 hours |
Pharmacology
Mechanism of Action: 2C-B acts as a partial agonist at serotonin 5-HT2A and 5-HT2C receptors, with some activity at 5-HT2B receptors. It also has weak affinity for dopamine D2 receptors.
Metabolism: Metabolized in the liver primarily by CYP2D6 and CYP2C19 enzymes. Major metabolites include 4-bromo-2,5-dimethoxyphenethylamine and various hydroxylated derivatives.
Half-life: Approximately 2-4 hours, with effects typically lasting 4-8 hours.
Bioavailability: ~70% when taken orally, with peak plasma concentrations reached within 1-2 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Shulgin, A. T., & Shulgin, A. (1991). PiHKAL: A Chemical Love Story. Transform Press.
- • Glennon, R. A., et al. (1994). 2C-B: A new psychoactive phenylethylamine. Journal of Medicinal Chemistry, 37(8), 1056-1060.
- • de la Torre, R., et al. (2004). Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Therapeutic Drug Monitoring, 26(2), 137-144.
- • Rickli, A., et al. (2016). Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs). Neuropharmacology, 99, 546-553.
- • Information compiled from PsychonautWiki