5-MeO-DMT
Common Names: Methoxy-N, N-dimethyltryptamine, MeO-DMT, It, DMT
Psychoactive Effects
Positive Effects
- Euphoria
Neutral Effects
- Intense visual hallucinations
- Complete reality replacement
- Entity encounters
- Time dilation/compression
- Ego dissolution
- Transcendental experiences
Negative Effects
- Depression
- Anxiety
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Smoked | 1-3 mg | 3-8 mg | 8-15 mg | 15-25 mg | 25+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | Immediate (smoked) |
| Peak | 1-3 minutes |
| Total | 5-15 minutes |
| After effects | 15-30 minutes |
Pharmacology
Mechanism of Action: 5-MeO-DMT acts as a partial agonist at serotonin 5-HT1A and 5-HT2A receptors, with greater 5-HT1A activity than DMT.
Metabolism: Rapidly metabolized by monoamine oxidase (MAO) enzymes, particularly MAO-A.
Half-life: Very short, approximately 5-10 minutes when smoked/vaporized.
Bioavailability: ~50% when smoked/vaporized, but essentially 0% when taken orally without MAO inhibitors.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Nichols, D. E. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264-355.
- • Carbonaro, T. M., & Gatch, M. B. (2016). Neuropharmacology of N,N-dimethyltryptamine. Brain Research Bulletin, 126, 74-88.
- • Information compiled from PsychonautWiki