L-Theanine
Common Names: Theanine, L-, N5-ethyl-L-glutamine, It
Psychoactive Effects
Positive Effects
- Information not available
Neutral Effects
- Relaxation
- Reduced anxiety
- Enhanced focus
- Improved sleep quality
- Reduced stress
- Calmness
Negative Effects
- Anxiety
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 50-100 mg | 100-200 mg | 200-400 mg | 400-600 mg | 600+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | 30-60 minutes |
| Peak | 1-2 hours |
| Total | 4-6 hours |
| After effects | 6-8 hours |
Pharmacology
Mechanism of Action: L-theanine acts as a glutamate receptor antagonist and may increase GABA, serotonin, and dopamine levels, producing anxiolytic effects.
Metabolism: Metabolized in the liver primarily by CYP enzymes. Major metabolites include ethylamine and glutamic acid.
Half-life: Approximately 2-3 hours, with effects typically lasting 4-6 hours.
Bioavailability: ~98% when taken orally, with peak plasma concentrations reached within 1-2 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Nobre, A. C., et al. (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition, 17(S1), 167-168.
- • Kimura, K., et al. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology, 74(1), 39-45.
- • Information compiled from PsychonautWiki