Modafinil
Common Names: None listed
Psychoactive Effects
Positive Effects
- Energy
Neutral Effects
- Increased alertness
- Enhanced focus
- Reduced fatigue
- Increased heart rate
- Pupil dilation
- Dry mouth
Negative Effects
- Anxiety
- Depression
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 50-100 mg | 100-200 mg | 200-400 mg | 400-600 mg | 600+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | 30-60 minutes |
| Peak | 2-4 hours |
| Total | 8-12 hours |
| After effects | 6-12 hours |
Pharmacology
Mechanism of Action: Modafinil acts as a weak dopamine reuptake inhibitor and may affect orexin, histamine, and norepinephrine systems to promote wakefulness.
Metabolism: Metabolized in the liver primarily by CYP3A4 enzyme. Major metabolites include modafinil acid and modafinil sulfone.
Half-life: Approximately 12-15 hours, with effects typically lasting 8-12 hours.
Bioavailability: ~80% when taken orally, with peak plasma concentrations reached within 2-4 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Ballon, J. S., & Feifel, D. (2006). A systematic review of modafinil: potential clinical uses and mechanisms of action. Journal of Clinical Psychiatry, 67(4), 554-566.
- • Volkow, N. D., et al. (2009). Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA, 301(11), 1148-1154.
- • Information compiled from PsychonautWiki