Tramadol
Common Names: Ultram, Ralivia, Tramal, It
Psychoactive Effects
Positive Effects
- Euphoria
- Happiness
Neutral Effects
- Pain relief
- Euphoria
- Sedation
- Respiratory depression
- Constipation
- Pupil constriction
Negative Effects
- Anxiety
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 25-50 mg | 50-100 mg | 100-200 mg | 200-300 mg | 300+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | 30-60 minutes |
| Peak | 2-4 hours |
| Total | 4-6 hours |
| After effects | 6-12 hours |
Pharmacology
Mechanism of Action: Tramadol acts as a weak mu-opioid receptor agonist and a serotonin/norepinephrine reuptake inhibitor.
Metabolism: Metabolized in the liver primarily by CYP2D6 and CYP3A4 enzymes. Major metabolite is O-desmethyltramadol (M1).
Half-life: Approximately 5-7 hours, with effects typically lasting 4-6 hours.
Bioavailability: ~70% when taken orally, with peak plasma concentrations reached within 1-2 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Pasternak, G. W. (2014). Opioids and their receptors: are we there yet? Neuropharmacology, 76, 198-203.
- • Grond, S., & Sablotzki, A. (2004). Clinical pharmacology of tramadol. Clinical Pharmacokinetics, 43(13), 879-923.
- • Information compiled from PsychonautWiki